Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4114819..4115500 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA37_RS19130 Protein ID WP_031639878.1
Coordinates 4114819..4115184 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA37_RS19135 Protein ID WP_003145733.1
Coordinates 4115177..4115500 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS19100 (PALA37_03782) 4110812..4111246 - 435 WP_003158601.1 RidA family protein -
PALA37_RS19105 (PALA37_03783) 4111467..4112420 + 954 WP_023435500.1 LysR substrate-binding domain-containing protein -
PALA37_RS19110 (PALA37_03784) 4112393..4113277 - 885 WP_009875989.1 LysR family transcriptional regulator -
PALA37_RS19115 (PALA37_03785) 4113378..4113803 + 426 WP_023435499.1 VOC family protein -
PALA37_RS19120 (PALA37_03786) 4113834..4114106 - 273 WP_058172074.1 hypothetical protein -
PALA37_RS19125 4114313..4114555 + 243 WP_049955787.1 hypothetical protein -
PALA37_RS19130 4114819..4115184 + 366 WP_031639878.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA37_RS19135 (PALA37_03787) 4115177..4115500 + 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
PALA37_RS19140 (PALA37_03788) 4115870..4116958 - 1089 WP_128552468.1 DUF3396 domain-containing protein -
PALA37_RS19145 (PALA37_03789) 4116975..4117673 - 699 WP_270132630.1 VRR-NUC domain-containing protein -
PALA37_RS19150 (PALA37_03790) 4117670..4118188 - 519 WP_012614469.1 PAAR domain-containing protein -
PALA37_RS19155 4118362..4118697 - 336 Protein_3770 TM2 domain-containing protein -
PALA37_RS19160 (PALA37_03792) 4118938..4119576 - 639 WP_003109444.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13970.32 Da        Isoelectric Point: 4.8219

>T262210 WP_031639878.1 NZ_CP109850:4114819-4115184 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSDINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDYRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT262210 WP_003145733.1 NZ_CP109850:4115177-4115500 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References