Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3468886..3469481 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name higB Uniprot ID A0A6N0KDU0
Locus tag PALA37_RS16170 Protein ID WP_023436306.1
Coordinates 3468886..3469164 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA37_RS16175 Protein ID WP_003133769.1
Coordinates 3469176..3469481 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS16150 (PALA37_03199) 3464312..3465550 + 1239 WP_014603324.1 C69 family dipeptidase -
PALA37_RS16155 (PALA37_03200) 3465612..3466259 + 648 WP_003095021.1 carbonate dehydratase -
PALA37_RS16160 (PALA37_03201) 3466329..3468557 - 2229 WP_270132120.1 TonB-dependent receptor -
PALA37_RS16165 3468705..3468833 + 129 Protein_3186 integrase -
PALA37_RS16170 3468886..3469164 + 279 WP_023436306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA37_RS16175 (PALA37_03202) 3469176..3469481 + 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA37_RS16185 (PALA37_03204) 3469779..3470909 - 1131 WP_057384474.1 AraC family transcriptional regulator ligand-binding domain-containing protein -
PALA37_RS16190 (PALA37_03205) 3471204..3472130 + 927 WP_009316208.1 triacylglycerol lipase -
PALA37_RS16195 (PALA37_03206) 3472210..3473253 + 1044 WP_270132127.1 lipase secretion chaperone -
PALA37_RS16200 (PALA37_03207) 3473339..3474439 - 1101 WP_003099270.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10588.11 Da        Isoelectric Point: 7.2451

>T262208 WP_023436306.1 NZ_CP109850:3468886-3469164 [Pseudomonas aeruginosa]
MILTFRCDEARQLFETGLSRQWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT262208 WP_003133769.1 NZ_CP109850:3469176-3469481 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N0KDU0

Antitoxin

Source ID Structure

References