Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2226775..2227280 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA37_RS10505 Protein ID WP_003083773.1
Coordinates 2226999..2227280 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag PALA37_RS10500 Protein ID WP_003137009.1
Coordinates 2226775..2227002 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS10475 (PALA37_02083) 2221790..2223283 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PALA37_RS10480 (PALA37_02084) 2223452..2224879 + 1428 WP_023092260.1 GABA permease -
PALA37_RS10485 (PALA37_02085) 2224964..2225305 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA37_RS10490 (PALA37_02086) 2225378..2225878 - 501 WP_270135252.1 LEA type 2 family protein -
PALA37_RS10495 (PALA37_02087) 2225979..2226599 + 621 WP_003101226.1 hypothetical protein -
PALA37_RS10500 (PALA37_02088) 2226775..2227002 + 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
PALA37_RS10505 (PALA37_02089) 2226999..2227280 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA37_RS10510 (PALA37_02090) 2227580..2228488 + 909 WP_198341046.1 LysR family transcriptional regulator -
PALA37_RS10515 (PALA37_02091) 2228520..2228930 - 411 WP_003110659.1 aegerolysin family protein -
PALA37_RS10520 (PALA37_02092) 2229110..2229844 - 735 WP_023107524.1 GntR family transcriptional regulator -
PALA37_RS10525 (PALA37_02093) 2229945..2230631 - 687 WP_033888123.1 FadR/GntR family transcriptional regulator -
PALA37_RS10530 (PALA37_02094) 2230680..2232029 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T262207 WP_003083773.1 NZ_CP109850:2226999-2227280 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT262207 WP_003137009.1 NZ_CP109850:2226775-2227002 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References