Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 753951..755646 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PALA37_RS03630 Protein ID WP_270134469.1
Coordinates 754777..755646 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA37_RS03625 Protein ID WP_003112902.1
Coordinates 753951..754784 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS03605 (PALA37_00717) 749182..750666 - 1485 WP_270134464.1 aldehyde dehydrogenase -
PALA37_RS03610 (PALA37_00718) 750678..751481 - 804 WP_003130116.1 aspartate dehydrogenase -
PALA37_RS03615 (PALA37_00719) 751492..753174 - 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
PALA37_RS03620 (PALA37_00720) 753167..753964 - 798 WP_270134467.1 SDR family oxidoreductase -
PALA37_RS03625 (PALA37_00721) 753951..754784 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA37_RS03630 (PALA37_00722) 754777..755646 - 870 WP_270134469.1 alpha/beta hydrolase Toxin
PALA37_RS03635 (PALA37_00723) 755655..756185 - 531 WP_003112900.1 cupin domain-containing protein -
PALA37_RS03640 (PALA37_00724) 756199..756960 - 762 WP_023106074.1 SDR family oxidoreductase -
PALA37_RS03645 (PALA37_00725) 756966..757742 - 777 WP_003112898.1 ABC transporter permease -
PALA37_RS03650 (PALA37_00726) 757739..758746 - 1008 WP_023106073.1 ABC transporter substrate-binding protein -
PALA37_RS03655 (PALA37_00727) 758786..759637 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30405.71 Da        Isoelectric Point: 6.8092

>T262206 WP_270134469.1 NZ_CP109850:c755646-754777 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSACWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT262206 WP_003112902.1 NZ_CP109850:c754784-753951 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References