Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 492223..493731 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA37_RS02400 Protein ID WP_003119682.1
Coordinates 493144..493731 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PALA37_RS02395 Protein ID WP_003091607.1
Coordinates 492223..493077 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS02380 (PALA37_00472) 487643..487852 + 210 WP_003091604.1 cold-shock protein -
PALA37_RS02385 (PALA37_00473) 487912..489786 - 1875 WP_003117607.1 MFS transporter -
PALA37_RS02390 (PALA37_00474) 489961..492126 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA37_RS02395 (PALA37_00475) 492223..493077 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PALA37_RS02400 (PALA37_00476) 493144..493731 - 588 WP_003119682.1 GNAT family protein Toxin
PALA37_RS02405 (PALA37_00477) 493997..497476 + 3480 WP_270134338.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262205 WP_003119682.1 NZ_CP109850:c493731-493144 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT262205 WP_003091607.1 NZ_CP109850:c493077-492223 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References