Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3841863..3843084 Replicon chromosome
Accession NZ_CP109845
Organism Pseudomonas aeruginosa strain PALA33

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA33_RS17840 Protein ID WP_003102740.1
Coordinates 3842506..3843084 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA33_RS17835 Protein ID WP_003088112.1
Coordinates 3841863..3842417 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA33_RS17810 (PALA33_03531) 3837431..3837982 + 552 WP_016253541.1 helix-turn-helix domain-containing protein -
PALA33_RS17815 (PALA33_03532) 3837979..3838377 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA33_RS17820 (PALA33_03533) 3838390..3838713 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA33_RS17825 (PALA33_03534) 3839044..3839505 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA33_RS17830 (PALA33_03535) 3839510..3841705 + 2196 WP_023087567.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA33_RS17835 (PALA33_03536) 3841863..3842417 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA33_RS17840 (PALA33_03537) 3842506..3843084 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA33_RS17845 (PALA33_03538) 3843193..3844380 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA33_RS17850 (PALA33_03539) 3844370..3846541 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA33_RS17855 (PALA33_03540) 3846531..3847808 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262190 WP_003102740.1 NZ_CP109845:3842506-3843084 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262190 WP_003088112.1 NZ_CP109845:3841863-3842417 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References