Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5472621..5473216 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OBG92_RS25860 Protein ID WP_003113526.1
Coordinates 5472938..5473216 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OBG92_RS25855 Protein ID WP_034079919.1
Coordinates 5472621..5472926 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS25830 (OBG92_05086) 5467625..5468725 + 1101 WP_003151685.1 redox-regulated ATPase YchF -
OBG92_RS25835 (OBG92_05087) 5468797..5469846 - 1050 WP_058145931.1 lipase secretion chaperone -
OBG92_RS25840 (OBG92_05088) 5469927..5470856 - 930 WP_012077421.1 triacylglycerol lipase -
OBG92_RS25845 (OBG92_05089) 5471124..5472233 + 1110 WP_170870656.1 AraC family transcriptional regulator -
OBG92_RS25855 (OBG92_05091) 5472621..5472926 - 306 WP_034079919.1 HigA family addiction module antitoxin Antitoxin
OBG92_RS25860 5472938..5473216 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OBG92_RS25865 5473269..5473588 - 320 Protein_5110 tyrosine-type recombinase/integrase -
OBG92_RS25870 (OBG92_05092) 5473888..5474091 + 204 WP_033976173.1 hypothetical protein -
OBG92_RS25875 (OBG92_05093) 5474332..5476191 + 1860 WP_003156877.1 NERD domain-containing protein/DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T261975 WP_003113526.1 NZ_CP109657:c5473216-5472938 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11170.58 Da        Isoelectric Point: 4.4462

>AT261975 WP_034079919.1 NZ_CP109657:c5472926-5472621 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLTELDISPAALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References