Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3452211..3453432 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name vapC Uniprot ID A0A2R3IQG1
Locus tag OBG92_RS16115 Protein ID WP_034082650.1
Coordinates 3452854..3453432 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OBG92_RS16110 Protein ID WP_034082653.1
Coordinates 3452211..3452765 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS16085 (OBG92_03163) 3447780..3448331 + 552 WP_043101666.1 XRE family transcriptional regulator -
OBG92_RS16090 (OBG92_03164) 3448328..3448726 - 399 WP_033997206.1 NADH-quinone oxidoreductase subunit A -
OBG92_RS16095 (OBG92_03165) 3448739..3449062 - 324 WP_012076113.1 quaternary ammonium compound efflux SMR transporter SugE -
OBG92_RS16100 (OBG92_03166) 3449392..3449853 + 462 WP_012076114.1 (2Fe-2S)-binding protein -
OBG92_RS16105 (OBG92_03167) 3449858..3452053 + 2196 WP_264315190.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OBG92_RS16110 (OBG92_03168) 3452211..3452765 + 555 WP_034082653.1 helix-turn-helix transcriptional regulator Antitoxin
OBG92_RS16115 (OBG92_03169) 3452854..3453432 + 579 WP_034082650.1 HD domain-containing protein Toxin
OBG92_RS16120 (OBG92_03170) 3453541..3454728 - 1188 WP_012076116.1 HlyD family efflux transporter periplasmic adaptor subunit -
OBG92_RS16125 (OBG92_03171) 3454718..3456889 - 2172 WP_043104503.1 type I secretion system permease/ATPase -
OBG92_RS16130 (OBG92_03172) 3456879..3458156 - 1278 WP_003153546.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21906.80 Da        Isoelectric Point: 5.3821

>T261971 WP_034082650.1 NZ_CP109657:3452854-3453432 [Pseudomonas aeruginosa]
MSLELLKNRLDFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAYPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20379.48 Da        Isoelectric Point: 8.9546

>AT261971 WP_034082653.1 NZ_CP109657:3452211-3452765 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQAHAAELFGVAQSTISRWESGAQALRAEERTRLETLLGARLETAADRALARLVDGS
PQPMHLICDLTHRLLACSPARAAQFAVPLGDLLGRSLWPYCSEEILRQEAALDDLGWRELLAPPALEFASGTNASTIVPI
RRSRCRWTRLTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3IQG1

Antitoxin

Source ID Structure

References