Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2424186..2424824 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag OGV15_RS11745 Protein ID WP_001447010.1
Coordinates 2424648..2424824 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OGV15_RS11740 Protein ID WP_001270286.1
Coordinates 2424186..2424602 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS11720 (2419338) 2419338..2420279 - 942 WP_001251304.1 ABC transporter permease -
OGV15_RS11725 (2420280) 2420280..2421293 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OGV15_RS11730 (2421311) 2421311..2422456 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
OGV15_RS11735 (2422701) 2422701..2424107 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OGV15_RS11740 (2424186) 2424186..2424602 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OGV15_RS11745 (2424648) 2424648..2424824 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OGV15_RS11750 (2425046) 2425046..2425276 + 231 WP_000494244.1 YncJ family protein -
OGV15_RS11755 (2425368) 2425368..2427329 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OGV15_RS11760 (2427402) 2427402..2427938 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OGV15_RS11765 (2428030) 2428030..2429205 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T261860 WP_001447010.1 NZ_CP109601:c2424824-2424648 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT261860 WP_001270286.1 NZ_CP109601:c2424602-2424186 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References