Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1906398..1907052 Replicon chromosome
Accession NZ_CP107390
Organism Klebsiella pneumoniae strain CRKP_28

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH501_RS09405 Protein ID WP_004144731.1
Coordinates 1906398..1906805 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH501_RS09410 Protein ID WP_002916312.1
Coordinates 1906786..1907052 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH501_RS09385 1902398..1904131 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
OH501_RS09390 1904137..1904850 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH501_RS09395 1904873..1905769 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH501_RS09400 1905870..1906391 + 522 WP_002916308.1 flavodoxin FldB -
OH501_RS09405 1906398..1906805 - 408 WP_004144731.1 protein YgfX Toxin
OH501_RS09410 1906786..1907052 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH501_RS09415 1907298..1908281 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH501_RS09420 1908432..1909091 - 660 WP_002916317.1 hemolysin III family protein -
OH501_RS09425 1909255..1909566 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH501_RS09430 1909616..1910344 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH501_RS09435 1910463..1911896 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T261044 WP_004144731.1 NZ_CP107390:c1906805-1906398 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT261044 WP_002916312.1 NZ_CP107390:c1907052-1906786 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A378E4P6


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References