260727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2674317..2674942 Replicon chromosome
Accession NZ_CP107312
Organism Klebsiella pneumoniae strain CRKP_41

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH506_RS13210 Protein ID WP_002882817.1
Coordinates 2674317..2674700 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH506_RS13215 Protein ID WP_004150355.1
Coordinates 2674700..2674942 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH506_RS13195 2671683..2672585 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OH506_RS13200 2672582..2673217 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH506_RS13205 2673214..2674143 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH506_RS13210 2674317..2674700 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH506_RS13215 2674700..2674942 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH506_RS13220 2675147..2676064 + 918 WP_002882812.1 alpha/beta hydrolase -
OH506_RS13225 2676078..2677019 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH506_RS13230 2677064..2677501 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH506_RS13235 2677498..2678358 - 861 WP_002882807.1 virulence factor BrkB family protein -
OH506_RS13240 2678352..2678951 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T260727 WP_002882817.1 NZ_CP107312:c2674700-2674317 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT260727 WP_004150355.1 NZ_CP107312:c2674942-2674700 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References