260576

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2605226..2605888 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5937_RS13040 Protein ID WP_263950106.1
Coordinates 2605226..2605624 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N5937_RS13045 Protein ID WP_156653662.1
Coordinates 2605628..2605888 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS13020 (2601225) 2601225..2602313 + 1089 WP_159340366.1 AAA family ATPase -
N5937_RS13025 (2602333) 2602333..2603295 - 963 WP_263950104.1 helix-turn-helix domain-containing protein -
N5937_RS13030 (2603321) 2603321..2604100 - 780 WP_214421461.1 MBL fold metallo-hydrolase -
N5937_RS13035 (2604228) 2604228..2605031 - 804 WP_263950105.1 lipoprotein NlpA -
N5937_RS13040 (2605226) 2605226..2605624 - 399 WP_263950106.1 type II toxin-antitoxin system VapC family toxin Toxin
N5937_RS13045 (2605628) 2605628..2605888 - 261 WP_156653662.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N5937_RS13050 (2606006) 2606006..2607505 - 1500 WP_156653661.1 MDR family MFS transporter -
N5937_RS13055 (2607584) 2607584..2608243 + 660 WP_156653660.1 TetR/AcrR family transcriptional regulator -
N5937_RS13060 (2608240) 2608240..2608659 - 420 WP_263950107.1 GNAT family N-acetyltransferase -
N5937_RS13065 (2608982) 2608982..2609278 + 297 WP_103177671.1 YicS family protein -
N5937_RS13070 (2609315) 2609315..2610262 - 948 WP_103177670.1 LacI family DNA-binding transcriptional regulator -
N5937_RS13075 (2610557) 2610557..2610871 + 315 WP_103177669.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2594105..2605888 11783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14654.78 Da        Isoelectric Point: 5.5081

>T260576 WP_263950106.1 NZ_CP107262:c2605624-2605226 [Leclercia adecarboxylata]
MLHMLDTNIVSHLVRQHPGVVNHYSRLAPEDMCISSVAEAELLYGVAKKQSLRLHETISEFLKTITVCDWDSDAAAIYGK
LRAEMEKRGKVMGDLDQLIAAHAISRGTTIVTNDQAFAMVQELTVEDWTTAA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10222.60 Da        Isoelectric Point: 9.8083

>AT260576 WP_156653662.1 NZ_CP107262:c2605888-2605628 [Leclercia adecarboxylata]
MERKAKLFKKGRNQAVLLPAEFAFDAESVWIRRDEEGNVVLRAMSEKERHRENFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References