Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718428..1718648 Replicon chromosome
Accession NZ_CP107112
Organism Clostridioides difficile strain R_cdtRKO8.1

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag OGM25_RS08105 Protein ID WP_003429855.1
Coordinates 1718428..1718589 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718509..1718648 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM25_RS08075 (OGM25_08075) 1714285..1714722 + 438 WP_009888839.1 hypothetical protein -
OGM25_RS08080 (OGM25_08080) 1714715..1714891 + 177 WP_009888840.1 hypothetical protein -
OGM25_RS08085 (OGM25_08085) 1714892..1716202 + 1311 WP_009893136.1 phage tail sheath family protein -
OGM25_RS08090 (OGM25_08090) 1716219..1716689 + 471 WP_009888842.1 phage tail tube protein -
OGM25_RS08095 (OGM25_08095) 1716748..1717575 + 828 WP_009888843.1 hypothetical protein -
OGM25_RS08100 (OGM25_08100) 1717647..1718087 + 441 WP_003429853.1 phage portal protein -
OGM25_RS08105 (OGM25_08105) 1718428..1718589 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718509..1718648 - 140 - - Antitoxin
OGM25_RS08110 (OGM25_08110) 1719926..1720114 + 189 WP_003429858.1 hypothetical protein -
OGM25_RS08115 (OGM25_08115) 1720233..1721099 + 867 WP_009888845.1 BRO family protein -
OGM25_RS08120 (OGM25_08120) 1721152..1721286 + 135 WP_009888846.1 hypothetical protein -
OGM25_RS08125 (OGM25_08125) 1721964..1722491 + 528 WP_009888847.1 DUF4352 domain-containing protein -
OGM25_RS08130 (OGM25_08130) 1722629..1723396 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1684639..1751776 67137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T260538 WP_003429855.1 NZ_CP107112:1718428-1718589 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 140 bp

>AT260538 NZ_CP107112:c1718648-1718509 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References