Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 6668294..6669802 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA20_RS31480 Protein ID WP_073660237.1
Coordinates 6669215..6669802 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PALA20_RS31475 Protein ID WP_003091607.1
Coordinates 6668294..6669148 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS31460 (PALA20_06221) 6663713..6663922 + 210 WP_003091604.1 cold-shock protein -
PALA20_RS31465 (PALA20_06222) 6663983..6665857 - 1875 WP_003091605.1 MFS transporter -
PALA20_RS31470 (PALA20_06223) 6666032..6668197 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA20_RS31475 (PALA20_06224) 6668294..6669148 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PALA20_RS31480 (PALA20_06225) 6669215..6669802 - 588 WP_073660237.1 GNAT family protein Toxin
PALA20_RS31485 (PALA20_06226) 6670068..6673547 + 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T260505 WP_073660237.1 NZ_CP107064:c6669802-6669215 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLVEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT260505 WP_003091607.1 NZ_CP107064:c6669148-6668294 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References