Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3644566..3645824 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA20_RS17140 Protein ID WP_003086331.1
Coordinates 3645069..3645824 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA20_RS17135 Protein ID WP_003086329.1
Coordinates 3644566..3644934 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS17115 (PALA20_03383) 3640729..3641004 + 276 WP_023098713.1 zinc ribbon domain-containing protein -
PALA20_RS17120 (PALA20_03384) 3641007..3641483 - 477 WP_003086322.1 hypothetical protein -
PALA20_RS17125 (PALA20_03385) 3641562..3643151 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA20_RS17130 (PALA20_03386) 3643207..3644493 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA20_RS17135 (PALA20_03387) 3644566..3644934 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA20_RS17140 (PALA20_03388) 3645069..3645824 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA20_RS17145 (PALA20_03389) 3646594..3647955 + 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA20_RS17150 (PALA20_03390) 3648110..3650653 - 2544 WP_003134033.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T260501 WP_003086331.1 NZ_CP107064:3645069-3645824 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT260501 WP_003086329.1 NZ_CP107064:3644566-3644934 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References