Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 894012..894669 Replicon chromosome
Accession NZ_CP107040
Organism Klebsiella oxytoca strain TYL-T1

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag NQA44_RS04330 Protein ID WP_004105559.1
Coordinates 894259..894669 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag NQA44_RS04325 Protein ID WP_004105561.1
Coordinates 894012..894278 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQA44_RS04310 (NQA44_04310) 889265..889690 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
NQA44_RS04315 (NQA44_04315) 889811..892609 - 2799 WP_023321613.1 transcriptional regulator DagR -
NQA44_RS04320 (NQA44_04320) 892785..893768 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
NQA44_RS04325 (NQA44_04325) 894012..894278 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
NQA44_RS04330 (NQA44_04330) 894259..894669 + 411 WP_004105559.1 protein YgfX Toxin
NQA44_RS04335 (NQA44_04335) 894678..895199 - 522 WP_004105557.1 flavodoxin FldB -
NQA44_RS04340 (NQA44_04340) 895321..896217 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
NQA44_RS04345 (NQA44_04345) 896240..896953 + 714 WP_023321612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NQA44_RS04350 (NQA44_04350) 896959..898692 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T260468 WP_004105559.1 NZ_CP107040:894259-894669 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT260468 WP_004105561.1 NZ_CP107040:894012-894278 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References