Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2966991..2967648 Replicon chromosome
Accession NZ_CP106838
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag N6B35_RS14105 Protein ID WP_004854060.1
Coordinates 2967238..2967648 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag N6B35_RS14100 Protein ID WP_004124953.1
Coordinates 2966991..2967257 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS14085 (N6B35_14085) 2962225..2962650 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
N6B35_RS14090 (N6B35_14090) 2962771..2965569 - 2799 WP_014226794.1 transcriptional regulator DagR -
N6B35_RS14095 (N6B35_14095) 2965763..2966746 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
N6B35_RS14100 (N6B35_14100) 2966991..2967257 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
N6B35_RS14105 (N6B35_14105) 2967238..2967648 + 411 WP_004854060.1 protein YgfX Toxin
N6B35_RS14110 (N6B35_14110) 2967657..2968178 - 522 WP_014226792.1 flavodoxin FldB -
N6B35_RS14115 (N6B35_14115) 2968300..2969196 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
N6B35_RS14120 (N6B35_14120) 2969219..2969932 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6B35_RS14125 (N6B35_14125) 2969938..2971671 + 1734 WP_032751182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T259882 WP_004854060.1 NZ_CP106838:2967238-2967648 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT259882 WP_004124953.1 NZ_CP106838:2966991-2967257 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References