Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 951384..952039 Replicon chromosome
Accession NZ_CP106819
Organism Neisseria gonorrhoeae strain 10791

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag LLE39_RS04905 Protein ID WP_003691083.1
Coordinates 951384..951803 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE39_RS04910 Protein ID WP_003688410.1
Coordinates 951803..952039 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE39_RS04885 (LLE39_04885) 946618..948159 - 1542 WP_003691084.1 MDR family MFS transporter -
LLE39_RS04890 (LLE39_04890) 948307..949086 + 780 WP_003688416.1 (Fe-S)-binding protein -
LLE39_RS04895 (LLE39_04895) 949083..949784 + 702 WP_003688414.1 lactate utilization protein C -
LLE39_RS04900 (LLE39_04900) 949781..951235 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE39_RS04905 (LLE39_04905) 951384..951803 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
LLE39_RS04910 (LLE39_04910) 951803..952039 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE39_RS04915 (LLE39_04915) 952486..953064 - 579 WP_003697246.1 IS3 family transposase -
LLE39_RS04920 (LLE39_04920) 953069..953359 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
LLE39_RS04925 (LLE39_04925) 953709..954095 + 387 Protein_967 transposase -
LLE39_RS04930 (LLE39_04930) 954478..955368 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
LLE39_RS04935 (LLE39_04935) 955379..956545 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE39_RS04940 (LLE39_04940) 956617..956904 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259857 WP_003691083.1 NZ_CP106819:c951803-951384 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259857 WP_003688410.1 NZ_CP106819:c952039-951803 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References