Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 661310..661965 Replicon chromosome
Accession NZ_CP106813
Organism Neisseria gonorrhoeae strain 9431

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OCL45_RS03525 Protein ID WP_003691083.1
Coordinates 661546..661965 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OCL45_RS03520 Protein ID WP_003688410.1
Coordinates 661310..661546 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCL45_RS03490 (OCL45_03490) 656449..656736 + 288 WP_003688407.1 hypothetical protein -
OCL45_RS03495 (OCL45_03495) 656808..657974 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
OCL45_RS03500 (OCL45_03500) 657985..658875 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
OCL45_RS03505 (OCL45_03505) 659258..659644 - 387 Protein_685 transposase -
OCL45_RS03510 (OCL45_03510) 659883..660284 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
OCL45_RS03515 (OCL45_03515) 660508..660798 + 291 WP_263055893.1 hypothetical protein -
OCL45_RS03520 (OCL45_03520) 661310..661546 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OCL45_RS03525 (OCL45_03525) 661546..661965 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OCL45_RS03530 (OCL45_03530) 662114..663568 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OCL45_RS03535 (OCL45_03535) 663565..664266 - 702 WP_003688414.1 lactate utilization protein C -
OCL45_RS03540 (OCL45_03540) 664263..665042 - 780 WP_003688416.1 (Fe-S)-binding protein -
OCL45_RS03545 (OCL45_03545) 665190..666731 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 659192..659665 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259849 WP_003691083.1 NZ_CP106813:661546-661965 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259849 WP_003688410.1 NZ_CP106813:661310-661546 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References