Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3520273..3521494 | Replicon | chromosome |
| Accession | NZ_CP106680 | ||
| Organism | Pseudomonas aeruginosa strain PALA11 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA11_RS16275 | Protein ID | WP_003160088.1 |
| Coordinates | 3520916..3521494 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA11_RS16270 | Protein ID | WP_023085114.1 |
| Coordinates | 3520273..3520827 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA11_RS16245 (PALA11_03229) | 3515841..3516392 | + | 552 | WP_003450159.1 | XRE family transcriptional regulator | - |
| PALA11_RS16250 (PALA11_03230) | 3516389..3516787 | - | 399 | WP_023089053.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA11_RS16255 (PALA11_03231) | 3516800..3517123 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA11_RS16260 (PALA11_03232) | 3517454..3517915 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA11_RS16265 (PALA11_03233) | 3517920..3520115 | + | 2196 | WP_014603034.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA11_RS16270 (PALA11_03234) | 3520273..3520827 | + | 555 | WP_023085114.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA11_RS16275 (PALA11_03235) | 3520916..3521494 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
| PALA11_RS16280 (PALA11_03236) | 3521603..3522790 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA11_RS16285 (PALA11_03237) | 3522780..3524951 | - | 2172 | WP_009876279.1 | type I secretion system permease/ATPase | - |
| PALA11_RS16290 (PALA11_03238) | 3524941..3526218 | - | 1278 | WP_125027955.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T259633 WP_003160088.1 NZ_CP106680:3520916-3521494 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20470.63 Da Isoelectric Point: 8.1590
>AT259633 WP_023085114.1 NZ_CP106680:3520273-3520827 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQSLARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQSLARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|