Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 731110..731705 Replicon chromosome
Accession NZ_CP104867
Organism Pseudomonas aeruginosa strain PALA6

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA6_RS03435 Protein ID WP_003117425.1
Coordinates 731110..731388 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA6_RS03440 Protein ID WP_003113527.1
Coordinates 731400..731705 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA6_RS03415 (PALA6_00685) 726537..727775 + 1239 WP_003117424.1 C69 family dipeptidase -
PALA6_RS03420 (PALA6_00686) 727837..728483 + 647 Protein_676 carbonate dehydratase -
PALA6_RS03425 (PALA6_00687) 728553..730781 - 2229 WP_269975426.1 TonB-dependent receptor -
PALA6_RS03430 730929..731057 + 129 Protein_678 integrase -
PALA6_RS03435 731110..731388 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA6_RS03440 (PALA6_00688) 731400..731705 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA6_RS03450 (PALA6_00690) 732111..733211 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA6_RS03455 (PALA6_00691) 733252..733836 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA6_RS03460 (PALA6_00692) 733878..734492 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA6_RS03465 (PALA6_00693) 734609..735550 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA6_RS03475 (PALA6_00695) 735717..736565 - 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259408 WP_003117425.1 NZ_CP104867:731110-731388 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259408 WP_003113527.1 NZ_CP104867:731400-731705 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References