Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2811971..2812680 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag BCGMEX_RS13150 Protein ID WP_003413164.1
Coordinates 2811971..2812384 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag BCGMEX_RS13155 Protein ID WP_003413167.1
Coordinates 2812423..2812680 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS13120 2807681..2807995 + 315 WP_009937839.1 hypothetical protein -
BCGMEX_RS13125 2808291..2809502 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
BCGMEX_RS13130 2809629..2810288 + 660 WP_003900846.1 LppA family lipoprotein -
BCGMEX_RS13135 2810285..2810944 + 660 WP_003900847.1 hypothetical protein -
BCGMEX_RS13140 2810941..2811603 + 663 WP_003900848.1 hypothetical protein -
BCGMEX_RS13145 2811600..2811878 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
BCGMEX_RS13150 2811971..2812384 + 414 WP_003413164.1 PIN domain nuclease Toxin
BCGMEX_RS13155 2812423..2812680 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
BCGMEX_RS13160 2812677..2813054 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
BCGMEX_RS13165 2813070..2813444 - 375 WP_003413177.1 hypothetical protein -
BCGMEX_RS13170 2813544..2813939 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
BCGMEX_RS13175 2813936..2814181 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
BCGMEX_RS13180 2814592..2815011 - 420 WP_003413190.1 A24 family peptidase -
BCGMEX_RS13185 2815023..2815850 - 828 WP_010950736.1 shikimate dehydrogenase -
BCGMEX_RS13190 2815828..2817081 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
BCGMEX_RS13195 2817074..2817586 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T25916 WP_003413164.1 NC_016804:2811971-2812384 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T25916 NC_016804:2811971-2812384 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT25916 WP_003413167.1 NC_016804:2812423-2812680 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT25916 NC_016804:2812423-2812680 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References