Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 54914..55572 Replicon plasmid punamed1
Accession NZ_CP104787
Organism Acinetobacter baumannii strain Ab-3556

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7E56_RS19245 Protein ID WP_000312250.1
Coordinates 54914..55273 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7E56_RS19250 Protein ID WP_001096429.1
Coordinates 55273..55572 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E56_RS19215 50420..50734 - 315 WP_000708714.1 hypothetical protein -
N7E56_RS19220 51804..52562 - 759 WP_001053129.1 hypothetical protein -
N7E56_RS19225 52629..53012 - 384 WP_000654349.1 hypothetical protein -
N7E56_RS19230 53151..53849 - 699 WP_000873190.1 hypothetical protein -
N7E56_RS19235 53916..54098 - 183 WP_000373385.1 hypothetical protein -
N7E56_RS19240 54147..54713 - 567 WP_041171756.1 hypothetical protein -
N7E56_RS19245 54914..55273 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7E56_RS19250 55273..55572 + 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
N7E56_RS19255 55673..55936 + 264 WP_000110863.1 hypothetical protein -
N7E56_RS19260 56029..56511 - 483 WP_001052677.1 hypothetical protein -
N7E56_RS19265 57134..57670 - 537 WP_000731981.1 hypothetical protein -
N7E56_RS19270 57720..58274 - 555 WP_000790085.1 hypothetical protein -
N7E56_RS19275 58355..58864 - 510 WP_001043199.1 hypothetical protein -
N7E56_RS19280 58904..59533 - 630 WP_002081923.1 hypothetical protein -
N7E56_RS19285 59550..59729 - 180 WP_002081921.1 hypothetical protein -
N7E56_RS19290 59705..60277 - 573 WP_000429351.1 hypothetical protein -
N7E56_RS19295 60282..60539 - 258 WP_000834292.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71276 71276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T259156 WP_000312250.1 NZ_CP104787:54914-55273 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT259156 WP_001096429.1 NZ_CP104787:55273-55572 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References