Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2324904..2325599 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag BCGMEX_RS10805 Protein ID WP_003410811.1
Coordinates 2324904..2325338 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag BCGMEX_RS10810 Protein ID WP_003410814.1
Coordinates 2325345..2325599 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS10795 2321058..2324099 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
BCGMEX_RS10800 2324092..2324925 + 834 WP_003899172.1 SWIM zinc finger family protein -
BCGMEX_RS10805 2324904..2325338 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS10810 2325345..2325599 - 255 WP_003410814.1 antitoxin Antitoxin
BCGMEX_RS10815 2325615..2325872 - 258 WP_003410816.1 hypothetical protein -
BCGMEX_RS10820 2326819..2327115 + 297 WP_003410820.1 PE family protein -
BCGMEX_RS10825 2327171..2327902 + 732 WP_003900467.1 PPE family protein -
BCGMEX_RS10830 2328442..2329188 - 747 WP_003901330.1 proteasome subunit alpha -
BCGMEX_RS10835 2329185..2330060 - 876 WP_003411023.1 proteasome subunit beta -
BCGMEX_RS10840 2330057..2330251 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T25912 WP_003410811.1 NC_016804:c2325338-2324904 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T25912 NC_016804:c2325338-2324904 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT25912 WP_003410814.1 NC_016804:c2325599-2325345 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT25912 NC_016804:c2325599-2325345 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References