Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | orf9-orf10/- |
| Location | 86942..88326 | Replicon | plasmid pHJ.T1 |
| Accession | NZ_CP104729 | ||
| Organism | Lysinibacillus fusiformis strain HJ.T1 | ||
Toxin (Protein)
| Gene name | ORF9 | Uniprot ID | - |
| Locus tag | N5069_RS23795 | Protein ID | WP_012291646.1 |
| Coordinates | 87781..88326 (-) | Length | 182 a.a. |
Antitoxin (Protein)
| Gene name | ORF10 | Uniprot ID | B1I081 |
| Locus tag | N5069_RS23790 | Protein ID | WP_012291647.1 |
| Coordinates | 86942..87781 (-) | Length | 280 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5069_RS23770 (N5069_23770) | 83481..84524 | - | 1044 | WP_261613665.1 | hypothetical protein | - |
| N5069_RS23775 (N5069_23775) | 84988..85356 | - | 369 | WP_031417274.1 | hypothetical protein | - |
| N5069_RS23780 (N5069_23780) | 85644..85919 | - | 276 | WP_261613539.1 | hypothetical protein | - |
| N5069_RS23785 (N5069_23785) | 85964..86815 | - | 852 | WP_036146852.1 | hypothetical protein | - |
| N5069_RS23790 (N5069_23790) | 86942..87781 | - | 840 | WP_012291647.1 | hypothetical protein | Antitoxin |
| N5069_RS23795 (N5069_23795) | 87781..88326 | - | 546 | WP_012291646.1 | NYN domain-containing protein | Toxin |
| N5069_RS23800 (N5069_23800) | 88547..89035 | - | 489 | WP_261613540.1 | hypothetical protein | - |
| N5069_RS23805 (N5069_23805) | 89075..89605 | - | 531 | WP_261613541.1 | ATP-binding protein | - |
| N5069_RS23810 (N5069_23810) | 89689..90144 | - | 456 | WP_261613542.1 | hypothetical protein | - |
| N5069_RS23815 (N5069_23815) | 90248..90796 | - | 549 | WP_261613668.1 | DnaA/Hda family protein | - |
| N5069_RS23820 (N5069_23820) | 90786..91064 | - | 279 | WP_012291643.1 | DUF1292 domain-containing protein | - |
| N5069_RS23825 (N5069_23825) | 91072..92208 | - | 1137 | WP_012291642.1 | hypothetical protein | - |
| N5069_RS23830 (N5069_23830) | 92212..93306 | - | 1095 | WP_261613543.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..171063 | 171063 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 182 a.a. Molecular weight: 20304.38 Da Isoelectric Point: 9.4376
>T259079 WP_012291646.1 NZ_CP104729:c88326-87781 [Lysinibacillus fusiformis]
MKKTAILVDEMNVIQQLRRLGIHGFNPWNAFYQALQRWNGDKKGVKAFYCANVPKEDAEHEKRNNFFEGLINHNIKVSVG
TVVYDSNSRRIAKGVDVALALDIVEHARSGVQDIFICTGDADVVPAIIRAQELGSRVHVVVSRAIPAKNITLAADSVVRL
EDILETMPPHRIKYFAKERVS
MKKTAILVDEMNVIQQLRRLGIHGFNPWNAFYQALQRWNGDKKGVKAFYCANVPKEDAEHEKRNNFFEGLINHNIKVSVG
TVVYDSNSRRIAKGVDVALALDIVEHARSGVQDIFICTGDADVVPAIIRAQELGSRVHVVVSRAIPAKNITLAADSVVRL
EDILETMPPHRIKYFAKERVS
Download Length: 546 bp
Antitoxin
Download Length: 280 a.a. Molecular weight: 31528.09 Da Isoelectric Point: 5.2827
>AT259079 WP_012291647.1 NZ_CP104729:c87781-86942 [Lysinibacillus fusiformis]
METAPQEIFDLTLAKKTENEKELENAYRRIPDEYHDFIVLLEQKIKITDSRYFLAEEFITMGAYQDEKGIYLKIKKPYMT
VDGRIRMARDEHSKKEAKLIISEPQIIQVGNRICMNVTVESEIHGTATGTIEVNINGFGVDKKNPVANAQTSALGRALGF
LGYGIIGTAATASLDEATNLYNSLFASPSKEQVDPKKPEIKRVRICGPIEYKNNDLGYVQIQLETEEYVIMQIGKSLFRY
ENILVTNAVVKVRGWWNGEIFAAAPDQDIILDQNKKIVS
METAPQEIFDLTLAKKTENEKELENAYRRIPDEYHDFIVLLEQKIKITDSRYFLAEEFITMGAYQDEKGIYLKIKKPYMT
VDGRIRMARDEHSKKEAKLIISEPQIIQVGNRICMNVTVESEIHGTATGTIEVNINGFGVDKKNPVANAQTSALGRALGF
LGYGIIGTAATASLDEATNLYNSLFASPSKEQVDPKKPEIKRVRICGPIEYKNNDLGYVQIQLETEEYVIMQIGKSLFRY
ENILVTNAVVKVRGWWNGEIFAAAPDQDIILDQNKKIVS
Download Length: 840 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|