Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1943143..1943603 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag BCGMEX_RS09030 Protein ID WP_003408531.1
Coordinates 1943355..1943603 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag BCGMEX_RS09025 Protein ID WP_003408528.1
Coordinates 1943143..1943355 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS09010 1939621..1940808 - 1188 WP_003898992.1 nitrate transporter NarK -
BCGMEX_RS09015 1941095..1941379 + 285 WP_003408522.1 DUF1876 domain-containing protein -
BCGMEX_RS09020 1941393..1943075 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
BCGMEX_RS09025 1943143..1943355 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCGMEX_RS09030 1943355..1943603 + 249 WP_003408531.1 hypothetical protein Toxin
BCGMEX_RS09035 1943611..1944349 + 739 Protein_1762 hypothetical protein -
BCGMEX_RS09040 1944443..1946143 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
BCGMEX_RS09045 1946428..1946829 - 402 WP_010950586.1 hypothetical protein -
BCGMEX_RS09050 1946900..1947430 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T25903 WP_003408531.1 NC_016804:1943355-1943603 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T25903 NC_016804:1943355-1943603 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT25903 WP_003408528.1 NC_016804:1943143-1943355 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT25903 NC_016804:1943143-1943355 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References