Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2282013..2282752 Replicon chromosome
Accession NZ_CP104689
Organism Enterobacter hormaechei strain 2020CK-00376

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag N5929_RS10925 Protein ID WP_003857133.1
Coordinates 2282013..2282498 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N5929_RS10930 Protein ID WP_003857131.1
Coordinates 2282486..2282752 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5929_RS10905 (N5929_02885) 2278166..2278924 - 759 WP_261666235.1 trans-aconitate 2-methyltransferase -
N5929_RS10910 (N5929_02880) 2279009..2279593 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
N5929_RS10915 (N5929_02875) 2279680..2280438 + 759 WP_261666234.1 DeoR/GlpR family DNA-binding transcription regulator -
N5929_RS10920 (N5929_02870) 2280543..2281835 + 1293 WP_261666233.1 glycosyl hydrolase family 28 protein -
N5929_RS10925 (N5929_02865) 2282013..2282498 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
N5929_RS10930 (N5929_02860) 2282486..2282752 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N5929_RS10935 (N5929_02855) 2282816..2283745 - 930 WP_261666232.1 LysR family transcriptional regulator -
N5929_RS10940 (N5929_02850) 2283875..2285257 + 1383 WP_261666231.1 MFS transporter -
N5929_RS10945 (N5929_02845) 2285280..2286275 - 996 WP_015570513.1 DUF2891 domain-containing protein -
N5929_RS10950 (N5929_02840) 2286285..2287271 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2268109..2282752 14643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T259005 WP_003857133.1 NZ_CP104689:c2282498-2282013 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT259005 WP_003857131.1 NZ_CP104689:c2282752-2282486 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References