Detailed information of TA system TA258954

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3600447..3600869
• Replicon: chromosome
• Accession: NZ_CP104677
• Organism: Salmonella enterica strain PNUSAS036471

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V6CTL5
• Locus tag: N4534_RS17660
• Protein ID: WP_000994227.1
• Coordinates: 3600594..3600869 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3600447..3600859 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4534_RS17635	3595705..3596199	-	495	WP_000839694.1	Saf-pilin pilus formation protein SafA	-
N4534_RS17640	3596960..3597664	-	705	Protein_3450	integrase core domain-containing protein	-
N4534_RS17645	3597717..3598031	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
N4534_RS17650	3598098..3598376	-	279	WP_077905025.1	hypothetical protein	-
N4534_RS17655	3598692..3599159	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
-	3600447..3600859	-	413	-	-	Antitoxin
N4534_RS17660	3600594..3600869	+	276	WP_000994227.1	SymE family type I addiction module toxin	Toxin
N4534_RS17665	3600917..3601348	-	432	WP_000778566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3587807..3620964	33157
	-	inside	Genomic island	-	-	3587807..3622453	34646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10090.38 Da
• Isoelectric Point: 6.8602

>T258954 WP_000994227.1 NZ_CP104677:3600594-3600869 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEDAGFETGRSVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT258954 NZ_CP104677:c3600859-3600447 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAAATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCGT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V6CTL5

Antitoxin