Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2825333..2826132 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N5913_RS14875 Protein ID WP_000347273.1
Coordinates 2825668..2826132 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag N5913_RS14870 Protein ID WP_001302819.1
Coordinates 2825333..2825668 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS14855 (2821118) 2821118..2821888 - 771 WP_001058231.1 2-dehydro-3-deoxyglucarate aldolase -
N5913_RS14860 (2821904) 2821904..2823238 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N5913_RS14865 (2823613) 2823613..2825184 + 1572 WP_001273776.1 galactarate dehydratase -
N5913_RS14870 (2825333) 2825333..2825668 + 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5913_RS14875 (2825668) 2825668..2826132 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5913_RS14880 (2826187) 2826187..2826996 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N5913_RS14885 (2827245) 2827245..2828525 + 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5913_RS14890 (2828548) 2828548..2829021 + 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5913_RS14895 (2829032) 2829032..2829811 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5913_RS14900 (2829801) 2829801..2830679 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N5913_RS14905 (2830697) 2830697..2831131 + 435 WP_000948831.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T258856 WP_000347273.1 NZ_CP104649:2825668-2826132 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT258856 WP_001302819.1 NZ_CP104649:2825333-2825668 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References