Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5039827..5040298 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag N5932_RS25090 Protein ID WP_001303511.1
Coordinates 5040020..5040298 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag N5932_RS25085 Protein ID WP_001302048.1
Coordinates 5039827..5040018 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS25045 (5035034) 5035034..5035618 - 585 WP_000206793.1 DUF551 domain-containing protein -
N5932_RS25050 (5035675) 5035675..5036070 - 396 WP_001118159.1 DUF977 family protein -
N5932_RS25055 (5036086) 5036086..5036855 - 770 Protein_4880 DUF1627 domain-containing protein -
N5932_RS25060 (5036881) 5036881..5037621 - 741 WP_000788938.1 ATP-binding protein -
N5932_RS25065 (5037628) 5037628..5038590 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
N5932_RS25070 (5038613) 5038613..5039038 - 426 WP_000693943.1 toxin YdaT family protein -
N5932_RS25075 (5039035) 5039035..5039337 - 303 WP_000172738.1 transcriptional regulator -
N5932_RS25080 (5039435) 5039435..5039806 + 372 WP_001169686.1 hypothetical protein -
N5932_RS25085 (5039827) 5039827..5040018 + 192 WP_001302048.1 hypothetical protein Antitoxin
N5932_RS25090 (5040020) 5040020..5040298 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5932_RS25095 (5040651) 5040651..5040950 + 300 WP_001240334.1 hypothetical protein -
N5932_RS25100 (5041022) 5041022..5041240 + 219 WP_001171930.1 protein YdfC -
N5932_RS25105 (5041809) 5041809..5041997 + 189 WP_000449192.1 cell division inhibition protein DicB -
N5932_RS25110 (5041994) 5041994..5042185 + 192 WP_001090200.1 DUF1482 family protein -
N5932_RS25115 (5042278) 5042278..5043363 + 1086 Protein_4892 exonuclease -
N5932_RS25120 (5043414) 5043414..5044627 + 1214 WP_162829202.1 IS3-like element IS1203 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4957425..5048772 91347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T258805 WP_001303511.1 NZ_CP104645:5040020-5040298 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT258805 WP_001302048.1 NZ_CP104645:5039827-5040018 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References