Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1823033..1823664 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag N5932_RS09430 Protein ID WP_001259385.1
Coordinates 1823389..1823664 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5932_RS09425 Protein ID WP_000593555.1
Coordinates 1823033..1823392 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS09395 (1818145) 1818145..1818618 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
N5932_RS09400 (1818615) 1818615..1818896 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N5932_RS09405 (1818973) 1818973..1820331 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
N5932_RS09410 (1820324) 1820324..1821832 + 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
N5932_RS09415 (1821822) 1821822..1822091 + 270 WP_000933060.1 HPr family phosphocarrier protein -
N5932_RS09420 (1822123) 1822123..1822983 + 861 WP_001131788.1 class II aldolase -
N5932_RS09425 (1823033) 1823033..1823392 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5932_RS09430 (1823389) 1823389..1823664 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
N5932_RS09435 (1823737) 1823737..1824861 - 1125 WP_001301659.1 ABC transporter permease -
N5932_RS09440 (1824861) 1824861..1827596 - 2736 WP_000149110.1 ribosome-associated ATPase/putative transporter RbbA -
N5932_RS09445 (1827593) 1827593..1828660 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T258786 WP_001259385.1 NZ_CP104645:c1823664-1823389 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258786 WP_000593555.1 NZ_CP104645:c1823392-1823033 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References