Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4111745..4112261 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag N5927_RS20150 Protein ID WP_000220582.1
Coordinates 4111745..4112029 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N5927_RS20155 Protein ID WP_000212724.1
Coordinates 4112019..4112261 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS20135 (4106956) 4106956..4108608 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
N5927_RS20140 (4109017) 4109017..4111155 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N5927_RS20145 (4111277) 4111277..4111741 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5927_RS20150 (4111745) 4111745..4112029 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5927_RS20155 (4112019) 4112019..4112261 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5927_RS20160 (4112339) 4112339..4114252 - 1914 WP_001212142.1 BglG family transcription antiterminator -
N5927_RS20165 (4114269) 4114269..4115009 - 741 WP_000779259.1 KDGP aldolase family protein -
N5927_RS20170 (4115006) 4115006..4116124 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N5927_RS20175 (4116108) 4116108..4117241 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T258754 WP_000220582.1 NZ_CP104641:c4112029-4111745 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258754 WP_000212724.1 NZ_CP104641:c4112261-4112019 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References