Detailed information of TA system TA258744

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2437557..2437782
• Replicon: chromosome
• Accession: NZ_CP104641
• Organism: Salmonella enterica strain 1019942

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: N5927_RS11830
• Protein ID: WP_000813254.1
• Coordinates: 2437557..2437712 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2437724..2437782 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N5927_RS11795	2432664..2432945	-	282	WP_000445513.1	phage holin family protein	-
N5927_RS11800	2432935..2433123	-	189	WP_001688615.1	putative holin	-
N5927_RS11805	2433117..2433440	-	324	Protein_2311	tellurite/colicin resistance protein	-
N5927_RS11810	2435611..2436147	-	537	WP_000640113.1	DUF1133 family protein	-
N5927_RS11815	2436144..2436434	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
N5927_RS11820	2436434..2437033	-	600	WP_000940751.1	DUF1367 family protein	-
N5927_RS11825	2437096..2437266	-	171	WP_000734094.1	hypothetical protein	-
N5927_RS11830	2437557..2437712	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2437724..2437782	+	59	-	-	Antitoxin
N5927_RS11835	2438139..2439071	+	933	WP_000556389.1	hypothetical protein	-
N5927_RS11840	2439068..2439622	+	555	WP_001033796.1	hypothetical protein	-
N5927_RS11845	2439784..2440113	-	330	WP_001676916.1	DUF977 family protein	-
N5927_RS11850	2440157..2440204	-	48	Protein_2320	hypothetical protein	-
N5927_RS11855	2440386..2440853	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
N5927_RS11860	2441238..2441393	+	156	WP_085981757.1	DUF1391 family protein	-
N5927_RS11865	2441501..2442022	-	522	WP_000004762.1	super-infection exclusion protein B	-
N5927_RS11870	2442460..2442681	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2432122..2443993	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T258744 WP_000813254.1 NZ_CP104641:c2437712-2437557 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT258744 NZ_CP104641:2437724-2437782 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin