Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 331073..331782 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID P9WF84
Locus tag BCGMEX_RS01460 Protein ID WP_003401406.1
Coordinates 331073..331501 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BRN8
Locus tag BCGMEX_RS01465 Protein ID WP_011799093.1
Coordinates 331525..331782 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS01435 326940..328073 - 1134 WP_003401394.1 hypothetical protein -
BCGMEX_RS01440 328070..328690 - 621 WP_003401397.1 TetR/AcrR family transcriptional regulator -
BCGMEX_RS01445 328787..329368 + 582 WP_003401399.1 VOC family protein -
BCGMEX_RS01450 329298..330023 - 726 WP_003902925.1 TetR/AcrR family transcriptional regulator -
BCGMEX_RS01455 330113..331033 + 921 WP_003401404.1 DUF2236 domain-containing protein -
BCGMEX_RS01460 331073..331501 - 429 WP_003401406.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS01465 331525..331782 - 258 WP_011799093.1 ribbon-helix-helix domain-containing protein Antitoxin
BCGMEX_RS01470 331867..334617 - 2751 WP_011799094.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15887.27 Da        Isoelectric Point: 7.2214

>T25874 WP_003401406.1 NC_016804:c331501-331073 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Download         Length: 429 bp

>T25874 NC_016804:c331501-331073 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.32 Da        Isoelectric Point: 10.6530

>AT25874 WP_011799093.1 NC_016804:c331782-331525 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT25874 NC_016804:c331782-331525 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGCACCACCGTGTCAATCTCCGATGAACTACTGGCTACCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGCACCGGCGGCGCCCGGCCAACCGTCCCCGTTTTTG
ACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGTCTGGAA
CTGAACTCGCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRN8

References