Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4471819..4472479 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag N4311_RS22850 Protein ID WP_000244756.1
Coordinates 4472066..4472479 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N4311_RS22845 Protein ID WP_000351186.1
Coordinates 4471819..4472085 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS22825 (4467751) 4467751..4469184 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
N4311_RS22830 (4469339) 4469339..4469653 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
N4311_RS22835 (4469814) 4469814..4470473 + 660 WP_000250289.1 hemolysin III family protein -
N4311_RS22840 (4470589) 4470589..4471569 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
N4311_RS22845 (4471819) 4471819..4472085 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N4311_RS22850 (4472066) 4472066..4472479 + 414 WP_000244756.1 protein YgfX Toxin
N4311_RS22855 (4472532) 4472532..4473053 - 522 WP_001055885.1 flavodoxin FldB -
N4311_RS22860 (4473166) 4473166..4474062 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
N4311_RS22865 (4474086) 4474086..4474799 + 714 WP_000745621.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4311_RS22870 (4474805) 4474805..4476538 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T258707 WP_000244756.1 NZ_CP104638:4472066-4472479 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT258707 WP_000351186.1 NZ_CP104638:4471819-4472085 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References