Detailed information of TA system TA258700

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 2492555..2492987
• Replicon: chromosome
• Accession: NZ_CP104638
• Organism: Salmonella enterica strain PNUSAS118466

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: N4311_RS13400
• Protein ID: WP_000994228.1
• Coordinates: 2492712..2492987 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2492555..2492977 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4311_RS13370	2487781..2488275	-	495	WP_000800125.1	hypothetical protein	-
N4311_RS13375	2489076..2489777	-	702	Protein_2438	integrase core domain-containing protein	-
N4311_RS13380	2489830..2490078	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
N4311_RS13385	2490210..2490488	-	279	WP_020924058.1	hypothetical protein	-
N4311_RS13390	2490805..2491272	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
N4311_RS13395	2492145..2492378	-	234	WP_124084119.1	hypothetical protein	-
-	2492555..2492977	-	423	-	-	Antitoxin
N4311_RS13400	2492712..2492987	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
N4311_RS13405	2493040..2493522	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
N4311_RS13410	2494041..2494487	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2479260..2516319	37059
	-	flank	IS/Tn	-	-	2489076..2489354	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T258700 WP_000994228.1 NZ_CP104638:2492712-2492987 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT258700 NZ_CP104638:c2492977-2492555 [Salmonella enterica]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin