Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 14015..14540 Replicon plasmid pHNAH8161B-3
Accession NZ_CP104607
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name ccdB Uniprot ID J5VBT8
Locus tag N5862_RS29985 Protein ID WP_004197633.1
Coordinates 14235..14540 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A9E1GDP8
Locus tag N5862_RS29980 Protein ID WP_004197642.1
Coordinates 14015..14233 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS29960 (N5862_29950) 10007..10711 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
N5862_RS29965 (N5862_29955) 10764..10997 - 234 Protein_13 BREX system Lon protease-like protein BrxL -
N5862_RS29970 (N5862_29960) 11676..12704 - 1029 WP_032445668.1 Abi family protein -
N5862_RS29975 (N5862_29965) 12865..13446 - 582 WP_072310991.1 hypothetical protein -
N5862_RS29980 (N5862_29970) 14015..14233 + 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
N5862_RS29985 (N5862_29975) 14235..14540 + 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB Toxin
N5862_RS29990 (N5862_29980) 14709..15104 + 396 WP_164530166.1 hypothetical protein -
N5862_RS29995 (N5862_29985) 15131..15454 + 324 WP_004197641.1 hypothetical protein -
N5862_RS30000 (N5862_29990) 15451..16467 + 1017 WP_164530167.1 hypothetical protein -
N5862_RS30005 (N5862_29995) 16665..17450 + 786 WP_046664219.1 site-specific integrase -
N5862_RS30010 (N5862_30000) 17899..18654 + 756 WP_001568031.1 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3'')-Ib / aph(6)-Id - 1..110502 110502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11585.27 Da        Isoelectric Point: 6.4661

>T258593 WP_004197633.1 NZ_CP104607:14235-14540 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8376.34 Da        Isoelectric Point: 4.7405

>AT258593 WP_004197642.1 NZ_CP104607:14015-14233 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MCG5

Antitoxin

Source ID Structure

References