Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2665943..2667531 Replicon chromosome
Accession NZ_CP104603
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5862_RS13320 Protein ID WP_064151580.1
Coordinates 2665943..2667265 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5862_RS13325 Protein ID WP_004176198.1
Coordinates 2667265..2667531 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS13305 (2660999) 2660999..2663500 + 2502 WP_284651106.1 fimbria/pilus outer membrane usher protein -
N5862_RS13310 (2663488) 2663488..2664492 + 1005 WP_064151581.1 fimbrial protein -
N5862_RS13315 (2664634) 2664634..2665926 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N5862_RS13320 (2665943) 2665943..2667265 - 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
N5862_RS13325 (2667265) 2667265..2667531 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5862_RS13330 (2667797) 2667797..2668123 - 327 WP_004176200.1 hydroxyisourate hydrolase -
N5862_RS13335 (2668120) 2668120..2668620 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5862_RS13340 (2668598) 2668598..2669977 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
N5862_RS13345 (2670323) 2670323..2671477 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N5862_RS13350 (2671458) 2671458..2672381 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T258579 WP_064151580.1 NZ_CP104603:c2667265-2665943 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT258579 WP_004176198.1 NZ_CP104603:c2667531-2667265 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References