Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3404930..3405548 Replicon chromosome
Accession NZ_CP104536
Organism Escherichia coli strain E3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O72_RS16540 Protein ID WP_001291435.1
Coordinates 3405330..3405548 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O72_RS16535 Protein ID WP_000344800.1
Coordinates 3404930..3405304 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O72_RS16525 (3400019) 3400019..3401212 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O72_RS16530 (3401235) 3401235..3404384 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O72_RS16535 (3404930) 3404930..3405304 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O72_RS16540 (3405330) 3405330..3405548 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O72_RS16545 (3405720) 3405720..3406271 + 552 WP_000102568.1 maltose O-acetyltransferase -
N5O72_RS16550 (3406387) 3406387..3406857 + 471 WP_000136192.1 YlaC family protein -
N5O72_RS16555 (3407021) 3407021..3408571 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O72_RS16560 (3408613) 3408613..3408966 - 354 Protein_3237 DUF1428 family protein -
N5O72_RS16570 (3409345) 3409345..3409656 + 312 WP_000409911.1 MGMT family protein -
N5O72_RS16575 (3409687) 3409687..3410259 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258361 WP_001291435.1 NZ_CP104536:3405330-3405548 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258361 WP_000344800.1 NZ_CP104536:3404930-3405304 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References