Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1313638..1314263 Replicon chromosome
Accession NZ_CP104536
Organism Escherichia coli strain E3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5O72_RS06420 Protein ID WP_000911330.1
Coordinates 1313865..1314263 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5O72_RS06415 Protein ID WP_000450524.1
Coordinates 1313638..1313865 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O72_RS06390 (1309441) 1309441..1309911 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N5O72_RS06395 (1309911) 1309911..1310483 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5O72_RS06400 (1310629) 1310629..1311507 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5O72_RS06405 (1311524) 1311524..1312558 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N5O72_RS06410 (1312771) 1312771..1313484 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5O72_RS06415 (1313638) 1313638..1313865 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5O72_RS06420 (1313865) 1313865..1314263 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N5O72_RS06425 (1314410) 1314410..1315273 + 864 WP_001267507.1 neutral zinc metallopeptidase -
N5O72_RS06430 (1315288) 1315288..1317303 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
N5O72_RS06435 (1317377) 1317377..1318075 + 699 WP_000679823.1 esterase -
N5O72_RS06440 (1318185) 1318185..1318385 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T258354 WP_000911330.1 NZ_CP104536:1313865-1314263 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258354 WP_000450524.1 NZ_CP104536:1313638-1313865 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References