25832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2193702..2194390 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag TBSG_RS10495 Protein ID WP_003409958.1
Coordinates 2193971..2194390 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag TBSG_RS10490 Protein ID WP_003409968.1
Coordinates 2193702..2193962 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS10465 2189193..2189792 - 600 WP_003409989.1 L-lysine exporter -
TBSG_RS10470 2189901..2190812 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBSG_RS10475 2190897..2191127 - 231 WP_003409980.1 DUF167 domain-containing protein -
TBSG_RS10480 2191242..2191895 + 654 WP_003409976.1 cutinase Cfp21 -
TBSG_RS10485 2191883..2193559 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
TBSG_RS10490 2193702..2193962 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBSG_RS10495 2193971..2194390 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
TBSG_RS10500 2194615..2195583 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
TBSG_RS10505 2195774..2196460 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
TBSG_RS10510 2196639..2198084 + 1446 WP_009938446.1 APC family permease -
TBSG_RS10515 2198047..2198895 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T25832 WP_003409958.1 NC_016768:2193971-2194390 [Mycobacterium tuberculosis KZN 4207]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T25832 NC_016768:2193971-2194390 [Mycobacterium tuberculosis KZN 4207]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT25832 WP_003409968.1 NC_016768:2193702-2193962 [Mycobacterium tuberculosis KZN 4207]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT25832 NC_016768:2193702-2193962 [Mycobacterium tuberculosis KZN 4207]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References