Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2742791..2743293 Replicon chromosome
Accession NZ_CP104521
Organism Escherichia coli strain E5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag N5O78_RS13525 Protein ID WP_000767832.1
Coordinates 2742791..2743045 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O78_RS13530 Protein ID WP_001259255.1
Coordinates 2743042..2743293 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O78_RS13495 (2737804) 2737804..2738031 - 228 WP_000985270.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N5O78_RS13500 (2738045) 2738045..2739103 - 1059 WP_096002838.1 thiosulfate utilization transporter TsuA/YeeE -
N5O78_RS13505 (2739283) 2739283..2740641 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5O78_RS13510 (2740631) 2740631..2740693 - 63 WP_010723108.1 membrane protein YoeI -
N5O78_RS13515 (2740909) 2740909..2741838 - 930 WP_000803370.1 LysR substrate-binding domain-containing protein -
N5O78_RS13520 (2741884) 2741884..2742708 - 825 WP_000754740.1 SDR family oxidoreductase -
N5O78_RS13525 (2742791) 2742791..2743045 - 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O78_RS13530 (2743042) 2743042..2743293 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O78_RS13535 (2743575) 2743575..2743625 + 51 WP_001364200.1 his operon leader peptide -
N5O78_RS13540 (2743771) 2743771..2744670 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N5O78_RS13545 (2744676) 2744676..2745980 + 1305 WP_024198577.1 histidinol dehydrogenase -
N5O78_RS13550 (2745977) 2745977..2747047 + 1071 WP_087899531.1 histidinol-phosphate transaminase -
N5O78_RS13555 (2747047) 2747047..2748114 + 1068 WP_029397756.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T258250 WP_000767832.1 NZ_CP104521:c2743045-2742791 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258250 WP_001259255.1 NZ_CP104521:c2743293-2743042 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References