Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4159366..4160201 Replicon chromosome
Accession NZ_CP104509
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag N5O74_RS21075 Protein ID WP_000854821.1
Coordinates 4159824..4160201 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N5O74_RS21070 Protein ID WP_261202994.1
Coordinates 4159366..4159734 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS21045 (4156768) 4156768..4157001 + 234 WP_001117568.1 DUF905 family protein -
N5O74_RS21050 (4157091) 4157091..4157909 + 819 WP_261202993.1 DUF932 domain-containing protein -
N5O74_RS21055 (4158001) 4158001..4158486 + 486 WP_032180519.1 antirestriction protein -
N5O74_RS21060 (4158502) 4158502..4158978 + 477 WP_001186768.1 RadC family protein -
N5O74_RS21065 (4159065) 4159065..4159286 + 222 WP_000692352.1 DUF987 domain-containing protein -
N5O74_RS21070 (4159366) 4159366..4159734 + 369 WP_261202994.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5O74_RS21075 (4159824) 4159824..4160201 + 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
N5O74_RS21080 (4160198) 4160198..4160395 + 198 Protein_4115 DUF5983 family protein -
N5O74_RS21085 (4160423) 4160423..4160620 + 198 WP_085949090.1 DUF957 domain-containing protein -
N5O74_RS21090 (4160705) 4160705..4161547 + 843 WP_111997887.1 DUF4942 domain-containing protein -
N5O74_RS21095 (4161828) 4161828..4162364 - 537 WP_000942785.1 GspM family type II secretion system protein YghD -
N5O74_RS21100 (4162408) 4162408..4163811 - 1404 Protein_4119 inorganic phosphate transporter PitB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T258201 WP_000854821.1 NZ_CP104509:4159824-4160201 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13729.64 Da        Isoelectric Point: 6.8422

>AT258201 WP_261202994.1 NZ_CP104509:4159366-4159734 [Escherichia coli]
VSDTLPRTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQTFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References