Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 55959..56686 | Replicon | plasmid pE80014967-1 |
| Accession | NZ_CP104468 | ||
| Organism | Enterobacter hormaechei strain 80014967 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A482LZ08 |
| Locus tag | NYP10_RS00295 | Protein ID | WP_045898923.1 |
| Coordinates | 55959..56270 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NYP10_RS00300 | Protein ID | WP_102752378.1 |
| Coordinates | 56267..56686 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYP10_RS00275 (NYP10_00275) | 51060..52577 | + | 1518 | WP_102752376.1 | FAD-dependent oxidoreductase | - |
| NYP10_RS00280 (NYP10_00280) | 52769..53557 | + | 789 | WP_261300411.1 | zinc-binding dehydrogenase | - |
| NYP10_RS00285 (NYP10_00285) | 53547..54815 | + | 1269 | WP_102752377.1 | MFS transporter | - |
| NYP10_RS00290 (NYP10_00290) | 54969..55211 | + | 243 | Protein_57 | Rid family hydrolase | - |
| NYP10_RS00295 (NYP10_00295) | 55959..56270 | + | 312 | WP_045898923.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NYP10_RS00300 (NYP10_00300) | 56267..56686 | + | 420 | WP_102752378.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NYP10_RS00305 (NYP10_00305) | 56969..57187 | - | 219 | Protein_60 | transposase | - |
| NYP10_RS00310 (NYP10_00310) | 57252..58399 | + | 1148 | WP_159413223.1 | IS3 family transposase | - |
| NYP10_RS00315 (NYP10_00315) | 58407..59777 | + | 1371 | WP_258004138.1 | Ig-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | dfrA14 / tet(A) / catA1 / ant(3'')-Ia / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / aac(3)-IIa / blaOXA-1 / aac(6')-Ib-cr / qnrB1 / blaNDM-1 | htpB | 1..206102 | 206102 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12347.07 Da Isoelectric Point: 9.7248
>T257972 WP_045898923.1 NZ_CP104468:55959-56270 [Enterobacter hormaechei]
MHVISKEPFEEAAKQYPNDSLAVRALYRLVRETDFSSPAEMRTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKQYPNDSLAVRALYRLVRETDFSSPAEMRTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15507.68 Da Isoelectric Point: 4.3573
>AT257972 WP_102752378.1 NZ_CP104468:56267-56686 [Enterobacter hormaechei]
MITDTAKAIEATKQLIAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEMPV
GVALLRTLIDQYRLSYSDLKEEIGSKSLVSQILSGQRSLTIMHIKALSARFGVKPEWFL
MITDTAKAIEATKQLIAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEMPV
GVALLRTLIDQYRLSYSDLKEEIGSKSLVSQILSGQRSLTIMHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|