Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1006219..1007834 Replicon chromosome
Accession NZ_CP104387
Organism Cupriavidus gilardii strain WM02

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N4G38_RS20865 Protein ID WP_252251685.1
Coordinates 1006219..1007568 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N4G38_RS20870 Protein ID WP_252251684.1
Coordinates 1007571..1007834 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G38_RS20855 (N4G38_20855) 1002886..1003821 + 936 WP_260732361.1 LysR family transcriptional regulator -
N4G38_RS20860 (N4G38_20860) 1004046..1006160 + 2115 WP_260732362.1 TonB-dependent siderophore receptor -
N4G38_RS20865 (N4G38_20865) 1006219..1007568 - 1350 WP_252251685.1 type II toxin-antitoxin system HipA family toxin Toxin
N4G38_RS20870 (N4G38_20870) 1007571..1007834 - 264 WP_252251684.1 helix-turn-helix transcriptional regulator Antitoxin
N4G38_RS20875 (N4G38_20875) 1008066..1008332 + 267 Protein_903 hypothetical protein -
N4G38_RS20880 (N4G38_20880) 1008483..1008833 + 351 WP_260732397.1 helix-turn-helix transcriptional regulator -
N4G38_RS20885 (N4G38_20885) 1008902..1010272 - 1371 WP_053823567.1 sigma-54 dependent transcriptional regulator -
N4G38_RS20890 (N4G38_20890) 1010331..1012043 - 1713 WP_260732363.1 TadG family pilus assembly protein -
N4G38_RS20895 (N4G38_20895) 1012049..1012417 - 369 WP_260732364.1 DUF3613 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 50088.23 Da        Isoelectric Point: 7.0049

>T257856 WP_252251685.1 NZ_CP104387:c1007568-1006219 [Cupriavidus gilardii]
MGRRSHTRTLTLWMNGAFVGTWHFSPRAGDVLQYAPEWVASGAGRPLSLSLPFTPGNAPHRGDKVRAYFDNLLPDTREIR
ERIARRYRTGSTDAFDLLAEIGRDCVGALQLLPDGTVPEGVQPVAAEPLTEAQVAQVLRGTLRSAPPGFVDEQDEFRISI
AGAQEKTALLYDNGAWCLPHGQTPTTHILKLPLGLVGGLKLNMTESVENEWLCSLILRQFGLPVAHCEPVQFEDLKALSV
QRFDRMWWQSPDGDRRLVRLPQEDMCQAKGVPPAFKYEADGGPGIDSIMETLAGSTTRDEDRRTFFQAQVLFWMLRATDG
HAKNFSLFLRPEGRYQLTPLYDVLSAYPIIGEAPGKLSPFRVKMAMAVRTRNAHYQMREIQRRHWLAVGERHGVITADGR
PARYVLDDLAERAPRVAQAIREALPKSFPEPLADCILDGMLAEAERLAG

Download         Length: 1350 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9488.96 Da        Isoelectric Point: 10.9887

>AT257856 WP_252251684.1 NZ_CP104387:c1007834-1007571 [Cupriavidus gilardii]
MSNFTVRTAEQLPQLLQAFRKEAGLTQAEAALRMGVSQQTLSALERNPARVSVDKLMRVLSVLGVELVLHKPAPQPHNGA
SSSPQVW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References