Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3541995..3542517 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag N4502_RS17065 Protein ID WP_001105433.1
Coordinates 3542227..3542517 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag N4502_RS17060 Protein ID WP_000212715.1
Coordinates 3541995..3542237 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS17040 (3537908) 3537908..3539281 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
N4502_RS17045 (3539364) 3539364..3539915 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
N4502_RS17050 (3540009) 3540009..3541361 + 1353 WP_039720329.1 metalloprotease PmbA -
N4502_RS17055 (3541417) 3541417..3541803 + 387 WP_001232253.1 cytochrome b562 -
N4502_RS17060 (3541995) 3541995..3542237 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4502_RS17065 (3542227) 3542227..3542517 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4502_RS17070 (3542518) 3542518..3542982 - 465 WP_260837258.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4502_RS17075 (3543168) 3543168..3545306 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
N4502_RS17080 (3545700) 3545700..3547355 - 1656 WP_001305655.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T257810 WP_001105433.1 NZ_CP104371:3542227-3542517 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT257810 WP_000212715.1 NZ_CP104371:3541995-3542237 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References