Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4083724..4083982 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag N2O69_RS20020 Protein ID WP_000809168.1
Coordinates 4083830..4083982 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4083724..4083781 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS20005 4079553..4080812 - 1260 WP_000494929.1 hypothetical protein -
N2O69_RS20010 4080941..4082434 - 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
N2O69_RS20015 4082454..4083215 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4083724..4083781 - 58 - - Antitoxin
N2O69_RS20020 4083830..4083982 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
N2O69_RS20025 4084087..4085217 - 1131 WP_001118464.1 molecular chaperone DnaJ -
N2O69_RS20030 4085306..4087222 - 1917 WP_000516135.1 molecular chaperone DnaK -
N2O69_RS20035 4087594..4087998 + 405 WP_000843687.1 DUF2541 family protein -
N2O69_RS20040 4088024..4088737 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T257448 WP_000809168.1 NZ_CP104274:4083830-4083982 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT257448 NZ_CP104274:c4083781-4083724 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References