Detailed information of TA system TA025735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 8791696..8792324
• Replicon: chromosome
• Accession: NC_016582
• Organism: Streptomyces bingchenggensis BCW-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D7C7E2
• Locus tag: SBI_RS36300
• Protein ID: WP_014179946.1
• Coordinates: 8791908..8792324 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D7C7E1
• Locus tag: SBI_RS36295
• Protein ID: WP_014179945.1
• Coordinates: 8791696..8791911 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBI_RS36280	8787230..8788264	-	1035	WP_014179941.1	LacI family transcriptional regulator	-
SBI_RS36285	8788482..8789804	+	1323	WP_014179942.1	MFS transporter	-
SBI_RS36290	8790335..8790961	+	627	WP_143675873.1	hypothetical protein	-
SBI_RS36295	8791696..8791911	+	216	WP_014179945.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SBI_RS36300	8791908..8792324	+	417	WP_014179946.1	PIN domain nuclease	Toxin
SBI_RS52000	8792294..8793121	+	828	WP_078610654.1	carboxylesterase family protein	-
SBI_RS36310	8793136..8793375	+	240	WP_014179948.1	hypothetical protein	-
SBI_RS36315	8793407..8794864	-	1458	WP_014179949.1	HAMP domain-containing histidine kinase	-
SBI_RS36320	8794857..8795543	-	687	WP_014179950.1	response regulator transcription factor	-
SBI_RS36325	8795692..8796381	+	690	WP_014179951.1	PepSY domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-43)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15098.10 Da
• Isoelectric Point: 4.9282

>T25735 WP_014179946.1 NC_016582:8791908-8792324 [Streptomyces bingchenggensis BCW-1]
MTDRYLIDKSALARYPKPAARAVIEPLHNAGLLAVCGAVELEVLHSARSKGDAERIRDEMRGFDWLPTPDEAWDRALEVQ
TQLIAAGNWKALSVSDLVIAATAERHSVIVLHYDGDYDMIAAVTGQSTRWVVPSGTAD

Nucleotide

• Length: 417 bp

>T25735 NC_016582:8791908-8792324 [Streptomyces bingchenggensis BCW-1]
ATGACCGATCGCTACCTCATCGACAAGTCCGCACTTGCCCGTTACCCGAAGCCGGCCGCTCGTGCGGTGATCGAGCCGCT
GCACAATGCGGGTCTGCTCGCCGTGTGCGGCGCCGTCGAGCTGGAGGTATTGCACAGTGCCCGTTCGAAGGGCGACGCGG
AACGCATCCGCGACGAGATGCGCGGCTTCGACTGGCTTCCGACCCCTGATGAGGCATGGGACCGTGCTCTGGAGGTGCAG
ACCCAGCTCATCGCGGCCGGTAACTGGAAGGCTCTCTCGGTATCGGACCTCGTGATCGCGGCGACCGCCGAACGTCACAG
CGTGATCGTCCTGCACTACGACGGCGACTACGACATGATCGCAGCCGTGACGGGGCAGTCAACGCGATGGGTTGTGCCCT
CTGGAACAGCAGACTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7548.53 Da
• Isoelectric Point: 4.3297

>AT25735 WP_014179945.1 NC_016582:8791696-8791911 [Streptomyces bingchenggensis BCW-1]
MARTVIDVDDEMLAEAAEIFGTTTKVATVNAALEDAIKRRKRASFLNWLAEGGLPDLTGPVEAPADPHQAA

Nucleotide

• Length: 216 bp

>AT25735 NC_016582:8791696-8791911 [Streptomyces bingchenggensis BCW-1]
ATGGCACGAACCGTCATTGATGTCGACGACGAGATGCTTGCCGAGGCCGCGGAGATCTTCGGCACCACGACGAAGGTCGC
CACGGTGAACGCCGCGCTGGAAGATGCGATCAAGCGCCGCAAGCGTGCATCGTTCCTGAACTGGCTTGCCGAAGGCGGCC
TGCCCGACCTGACGGGTCCCGTTGAGGCTCCGGCTGACCCGCACCAGGCTGCATGA

Structures

Toxin

• AlphaFold DB: D7C7E2

Antitoxin

• AlphaFold DB: D7C7E1