Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2407864..2409452 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N1705_RS11650 Protein ID WP_219411818.1
Coordinates 2408130..2409452 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N1705_RS11645 Protein ID WP_001296726.1
Coordinates 2407864..2408130 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS11635 (2403245) 2403245..2403942 + 698 WP_225103636.1 IS1 family transposase -
N1705_RS11640 (2403957) 2403957..2407655 + 3699 Protein_2277 ECSE_1600 family autotransporter -
N1705_RS11645 (2407864) 2407864..2408130 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N1705_RS11650 (2408130) 2408130..2409452 + 1323 WP_219411818.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N1705_RS11655 (2409759) 2409759..2409967 + 209 Protein_2280 AraC family transcriptional regulator -
N1705_RS11660 (2410400) 2410400..2410963 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
N1705_RS11665 (2411324) 2411324..2412034 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2407864..2424343 16479
- flank IS/Tn - - 2403649..2403942 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49489.23 Da        Isoelectric Point: 9.3070

>T257276 WP_219411818.1 NZ_CP104123:2408130-2409452 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT257276 WP_001296726.1 NZ_CP104123:2407864-2408130 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References