Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3849221..3849948 Replicon chromosome
Accession NZ_CP104112
Organism Escherichia coli strain USDA-ARS-USMARC-51688

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag N1707_RS18815 Protein ID WP_000550189.1
Coordinates 3849634..3849948 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1707_RS18810 Protein ID WP_000560255.1
Coordinates 3849221..3849637 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1707_RS18800 (3844481) 3844481..3846832 + 2352 WP_000695495.1 alpha-glucosidase -
N1707_RS18805 (3847158) 3847158..3849176 + 2019 WP_112032342.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
N1707_RS18810 (3849221) 3849221..3849637 - 417 WP_000560255.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
N1707_RS18815 (3849634) 3849634..3849948 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
N1707_RS18820 (3850233) 3850233..3851369 - 1137 WP_000018690.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
N1707_RS18825 (3851454) 3851454..3851956 + 503 Protein_3654 M48 family metallopeptidase -
N1707_RS18830 (3852033) 3852033..3852716 + 684 WP_001183041.1 vancomycin high temperature exclusion protein -
N1707_RS18835 (3852795) 3852795..3853781 + 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T257214 WP_000550189.1 NZ_CP104112:c3849948-3849634 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14951.41 Da        Isoelectric Point: 4.5577

>AT257214 WP_000560255.1 NZ_CP104112:c3849637-3849221 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References